What process does cocaine primarily use to create feelings of euphoria?

Cocaine primarily creates feelings of euphoria by blocking neurotransmitter reuptake. This means that when cocaine is consumed, it prevents the reabsorption of certain neurotransmitters, particularly dopamine, by the neurons that released them. Normally, after dopamine is released into the synaptic cleft (the space between neurons), it binds to receptors on the receiving neuron and is then reabsorbed back into the releasing neuron through reuptake transporters. By inhibiting this reuptake process, cocaine increases the amount of dopamine available in the synaptic cleft, leading to heightened stimulation of the receptor sites and an amplified sense of pleasure and euphoria.

This mechanism is significant because it alters the normal communication between neurons and reinforces feelings of reward and pleasure, which can contribute to the addictive properties of cocaine. Understanding this process is crucial for grasping how psychoactive substances can affect the brain's reward pathways and emotional responses.